Solubility and Dissolution Improvement of Aceclofenac using Different Nanocarriers

Solubility and Permeability Studies of Aceclofenac in Different Oils

Purpose: To measure the extent of solubility of the lipophilic drug, aceclofenac, in 13 oils as well as its in vitro permeability from these oils in order to develop optimized topical microemulsion and microemulsion-based gel for improved bioavailability. Methods: UV spectrophotometeric method was used at the wavelength of 276 nm to measure the dissolved quantity of aceclofenac in each of the o...

comparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods

هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...

development of different optical methods for determination of glucose using cadmium telluride quantum dots and silver nanoparticles

a simple, rapid and low-cost scanner spectroscopy method for the glucose determination by utilizing glucose oxidase and cdte/tga quantum dots as chromoionophore has been described. the detection was based on the combination of the glucose enzymatic reaction and the quenching effect of h2o2 on the cdte quantum dots (qds) photoluminescence.in this study glucose was determined by utilizing glucose...

Evaluation of Dissolution Hydrodynamics in the USP, PeakTM and Flat-Bottom Vessels Using Different Solubility Drugs

lyophilization monophase solution technique for improvement of the solubility and dissolution of piroxicam

piroxicam (px), an anti-inflammatory drug, exhibits poor water solubility, dissolution and flow properties. thus, the aim of the present study was to improve the solubility and dissolution rate of px by freeze drying technique using dimethylformamide (dmf), chloroform and water as co-solvent system. the prepared crystals containing px were evaluated for dmf and chloroform solvent residual by ga...